Current Studies / Online Screener


 

 

To contact us about participating in our research, please call Tom Hohing at 833-LiBI-BBL (833-542-4225), email LiBI [at] email.chop.edu, or complete our online screener HERE.

 

Intake and Screening Study

All participants who participate in Lifespan Brain Institute research complete these procedures to make sure we have accurate and detailed information about you, your family, your medical history, and your life experiences. If you decide to participate in more studies in the future, we may ask you to repeat these procedures periodically so we can make sure the information we have is up to date and also so we can see if anything changes over time.

  • This study involves:
    • The Computerized Neurocognitive Battery
    • An interview with either just you (if you're 18 or older) or you and a parent if you're under 18.
    • A saliva or blood sample
    • We'll also ask if you're willing to let us contact you again to see if you're interested in participating in any of our future studies.
    • As always, we will compensation you for your time and will cover any parking or transportation expenses.

The Computerized Neurocognitive Battery takes about 1 – 1.5 hours, the interview takes about 2.5 – 3 hours, and the consent and blood draw/saliva sample will take about 30 minutes, so the whole research visit will last about 5 – 6 hours.


Neuroimaging of Executive Function (Cognition) in Youth

We are recruiting participants (age 8-15) to participate in a research study. We are interested in studying decision making and cognition in youth over time. So, it is very important that you can return to complete the study visits up to 3 times over the next 5 years. At each time point, there will be two different study visits, the first involves the procedures as mentioned under the Intake and Screening Study. The second visit involves the following: 

  • This study involves:
    • An MRI scan 
    • Decision-making tasks
    • Self-report questionnaires 

The visit lasts about 3-4 hours and you would be compensated for your time and reimbursed for any parking or transportation expenses.


Melatonin, Sleep, and Mental Health Study

We are recruiting participants (age 11 - 30) who have mild sleep problems. The purpose of this research study is to see if supplemental melatonin improves sleep and the sleep-wake patterns (also known as circadian rhythm) in children, teenagers, and young adults with at-risk symptoms.

  • This study involves:
    • Taking an over-the-counter melatonin pill or placebo for 2 weeks
    • Computerized testing that measures memory and attention
    • An interview about your life experiences, thoughts, feelings and aspects of mental health
    • Collection of family and medical history
    • Optional blood draw, urine and saliva samples
    • We may also collect some information from your parents (when applicable)

Participants will be paid for their time and travel plus have access to mental health experts. Study includes 5 total visits over 6 months with the first and final visits lasting about 4 hours and between visits lasting about 1.5 hours each.


Adolescent Brain Development, Memory, and Motivation

The main purpose of this study is to understand how brain structure and function relate to behaviors, motivations, and thoughts, and how these change during adolescence and young adulthood. Brain structure and activity can be measured using a non-invasive technique called magnetic resonance imaging (MRI). Functional MRI (fMRI) tells us the pattern and distribution of blood flow in the brain, which change when brain activity changes. 

About 140 people ages 16-26 will participate in this study at the University of Pennsylvania. This study involves 4 visits in total over the course of about 2 years. The first two visits of the study will be completed within one month of each other (these are the baseline visits). The second two visits will be completed about two years later (these are the follow-up visits).

  • The study involves:
    • Consent (if you are over 18), or parental permission if you are under 18
    • 1-hour MRI scan
    • Computerized Neurocognitive Battery (CNB)
    • Interviews with either just you (if you are 18 or older), or with you and a parent if you are under 18
    • Computer games 
    • Questionnaires and surveys about your emotions and behavior

Each visit will last about 4-6 hours, and you will be paid for your participation and travel. 


Brain-Behavior and Genetic Studies of the 22q11.2 DS

(For more information about this study, please call Sean Gallagher at 215-906-5071)

We are recruiting participants into the Lifespan Brain Institute who have a diagnosis of 22q11.2 DS. This research aims to better understand brain and behavioral differences in individuals ages 8 years and older with the chromosome 22q11.2 deletion syndrome. By looking at individuals with the deletion, we may begin to better understand the risk factors associates with brain and behavior changes as people grow. Should you decide to participate in more studies in the future, we may ask you to repeat these procedures periodically so we can make sure the information we have is up to date and also so we can see how people change as they mature.

  • This study involves:
    • The Computerized Neurocognitive Battery
    • An interview with either just you (if you're 18 or older) or you and a parent if you're under 18.
    • A saliva or blood sample
    • We'll also ask if you're willing to let us contact you again to see if you're interested in participating in any of our future studies.
    • As always, we will compensation you for your time and will cover any parking or transportation expenses.

The Computerized Neurocognitive Battery takes about 1 – 1.5 hours, the interview takes about 2.5 – 3 hours, and the consent and blood draw/saliva sample will take about 30 minutes, so the whole research visit will last about 5 – 6 hours.


TMS Study

The University of Pennsylvania seeks young adults ages 18-28 for a research study. The purpose of this study is to use different types of MRI scans to find individualized TMS(transcranial magnetic stimulation) targets and compare how the brain responds. We are also interested in using TMS during a working memory test to see how it affects task performance. TMS involves a procedure during which your brain will be noninvasively (i.e. from the scalp) stimulated by magnetic pulses and MRI scans are used to take pictures of your brain. In this study we administer TMS inside of the MRI scanner so we can see how the stimulation affects the rest of the brain.

  • Participation Includes:
    • Visit 1: Initial Screening Session (4-6 hours)
    • Visit 2: MRI Scan and Interviews (2-4 hours)
    • Visit 3: MRI Scan with TMS (1.5 hours)
    • Visit 4 (healthy control participants only): MRI Scan with TMS (1.5 hours)
    • Visit 5: Task MRI Scan (1 hour)
    • Monetary Compensation

If you are interested in participating, please complete our online screening form at this link: https://is.gd/cndslab or give us a call at 215-746-2637