Current Studies / Online Screener


 

Resilience During COVID-19

 

Complete an online survey (~10min) to participate in a study examining the relationship of resilience and mental health during the COVID-19 pandemic.

 

After the survey, you will receive feedback on your own resilience and get personalized recommendations to improve your well-being during these difficult COVID-19 times.

 

You can participate in the study if you are 18 years of age and older. If you are between the ages of 8 and 17, you may participate with parent/guardian permission.

 

To complete the survey, please visit:

covid19resilience.org

 

We greatly appreciate your participation and contribution to science!

 

Principal Investigator: Ran Barzilay, MD PhD barzilayr [at] email.chop.edu

For more information call Ran Barzilay at (833) 542-4225


 

To contact us about participating in our research, please call Tom Hohing at 833-LiBI-BBL (833-542-4225), email LiBI [at] email.chop.edu, or complete our online screener HERE.

 

Intake and Screening Study

All participants who participate in Lifespan Brain Institute research complete these procedures to make sure we have accurate and detailed information about you, your family, your medical history, and your life experiences. If you decide to participate in more studies in the future, we may ask you to repeat these procedures periodically so we can make sure the information we have is up to date and also so we can see if anything changes over time.

  • This study involves:
    • The Computerized Neurocognitive Battery
    • An interview with either just you (if you're 18 or older) or you and a parent if you're under 18.
    • A saliva or blood sample
    • We'll also ask if you're willing to let us contact you again to see if you're interested in participating in any of our future studies.
    • As always, we will compensation you for your time and will cover any parking or transportation expenses.

The Computerized Neurocognitive Battery takes about 1 – 1.5 hours, the interview takes about 2.5 – 3 hours, and the consent and blood draw/saliva sample will take about 30 minutes, so the whole research visit will last about 5 – 6 hours.


Neuroimaging of Executive Function (Cognition) in Youth

We are recruiting participants (age 8-15) to participate in a research study. We are interested in studying decision making and cognition in youth over time. So, it is very important that you can return to complete the study visits up to 3 times over the next 5 years. At each time point, there will be two different study visits, the first involves the procedures as mentioned under the Intake and Screening Study. The second visit involves the following: 

  • This study involves:
    • An MRI scan 
    • Decision-making tasks
    • Self-report questionnaires 

The visit lasts about 3-4 hours and you would be compensated for your time and reimbursed for any parking or transportation expenses.


Melatonin, Sleep, and Mental Health Study

We are recruiting participants (age 11 - 30) who have mild sleep problems. The purpose of this research study is to see if supplemental melatonin improves sleep and the sleep-wake patterns (also known as circadian rhythm) in children, teenagers, and young adults with at-risk symptoms.

  • This study involves:
    • Taking an over-the-counter melatonin pill or placebo for 2 weeks
    • Computerized testing that measures memory and attention
    • An interview about your life experiences, thoughts, feelings and aspects of mental health
    • Collection of family and medical history
    • Optional blood draw, urine and saliva samples
    • We may also collect some information from your parents (when applicable)

Participants will be paid for their time and travel plus have access to mental health experts. Study includes 5 total visits over 6 months with the first and final visits lasting about 4 hours and between visits lasting about 1.5 hours each.


Adolescent Brain Development, Memory, and Motivation

The main purpose of this study is to understand how brain structure and function relate to behaviors, motivations, and thoughts, and how these change during adolescence and young adulthood. Brain structure and activity can be measured using a non-invasive technique called magnetic resonance imaging (MRI). Functional MRI (fMRI) tells us the pattern and distribution of blood flow in the brain, which change when brain activity changes. 

About 140 people ages 16-26 will participate in this study at the University of Pennsylvania. This study involves 4 visits in total over the course of about 2 years. The first two visits of the study will be completed within one month of each other (these are the baseline visits). The second two visits will be completed about two years later (these are the follow-up visits).

  • The study involves:
    • Consent (if you are over 18), or parental permission if you are under 18
    • 1-hour MRI scan
    • Computerized Neurocognitive Battery (CNB)
    • Interviews with either just you (if you are 18 or older), or with you and a parent if you are under 18
    • Computer games 
    • Questionnaires and surveys about your emotions and behavior

Each visit will last about 4-6 hours, and you will be paid for your participation and travel. 


Brain-Behavior and Genetic Studies of the 22q11.2 DS

(For more information about this study, please call Sean Gallagher at 215-906-5071)

We are recruiting participants into the Lifespan Brain Institute who have a diagnosis of 22q11.2 DS. This research aims to better understand brain and behavioral differences in individuals ages 8 years and older with the chromosome 22q11.2 deletion syndrome. By looking at individuals with the deletion, we may begin to better understand the risk factors associates with brain and behavior changes as people grow. Should you decide to participate in more studies in the future, we may ask you to repeat these procedures periodically so we can make sure the information we have is up to date and also so we can see how people change as they mature.

  • This study involves:
    • The Computerized Neurocognitive Battery
    • An interview with either just you (if you're 18 or older) or you and a parent if you're under 18.
    • A saliva or blood sample
    • We'll also ask if you're willing to let us contact you again to see if you're interested in participating in any of our future studies.
    • As always, we will compensation you for your time and will cover any parking or transportation expenses.

The Computerized Neurocognitive Battery takes about 1 – 1.5 hours, the interview takes about 2.5 – 3 hours, and the consent and blood draw/saliva sample will take about 30 minutes, so the whole research visit will last about 5 – 6 hours.


TMS Study

The University of Pennsylvania seeks young adults ages 18-28 for a research study. The purpose of this study is to use different types of MRI scans to find individualized TMS(transcranial magnetic stimulation) targets and compare how the brain responds. We are also interested in using TMS during a working memory test to see how it affects task performance. TMS involves a procedure during which your brain will be noninvasively (i.e. from the scalp) stimulated by magnetic pulses and MRI scans are used to take pictures of your brain. In this study we administer TMS inside of the MRI scanner so we can see how the stimulation affects the rest of the brain.

  • Participation Includes:
    • Visit 1: Initial Screening Session (4-6 hours)
    • Visit 2: MRI Scan and Interviews (2-4 hours)
    • Visit 3: MRI Scan with TMS (1.5 hours)
    • Visit 4 (healthy control participants only): MRI Scan with TMS (1.5 hours)
    • Visit 5: Task MRI Scan (1 hour)
    • Monetary Compensation

If you are interested in participating, please complete our online screening form at this link: https://is.gd/cndslab or give us a call at 215-746-2637


 The 1289-0032 Research Study

Are your thoughts tangled? You’re not sure how or why it happened, but you are aware of instances lately when it felt like you had no control over your thoughts. You couldn’t think clearly or concentrate, and you may have even heard or seen things that other people didn’t. While these were unsettling times, you eventually regained control of your thoughts. Still, you may be concerned about whether it will happen again and if it could be a sign of a more serious mental health condition.


Because you and others have experienced symptoms like these, local doctors are conducting the 1289-0032 Research Study. In this study, doctors want to evaluate the safety and effectiveness of an investigational drug and compare it to placebo, which looks like the investigational drug but contains no active medication. The investigational drug is not approved to treat any mental health condition.The results of this study will provide more information about the investigational drug and whether it could one day be used to help people who have experienced symptoms similar to yours.

 

Patients eligible for this study may have experienced symptoms such as:

  • Trouble thinking clearly or concentrating
  • Believing or hearing things that others do not
  • Losing control of their thoughts
  • Feeling nervous or anxious
  • Feeling that others are “out to get” them
  • Having trouble with family and friends
  • Having thoughts that scare them or the people around them
  • Having trouble at work or school

You may be able to participate in this study if you:

  • Are 16 to 30 years of age
  • Are experiencing one or more of the symptoms listed in this brochure
  • Have not been diagnosed with schizophrenia or related disorders, bipolar disorder I, or major depressive disorder with psychotic symptoms
  • Are not taking a medication called clozapine

 

The study staff will review additional eligibility requirements with you. All study-related visits, tests, and drugs will be provided at no cost. In addition, reimbursement for study-related time and travel may be provided.

Please visit www.1289-0032study.com to learn more.


Evolition of Psychosis in Youth

The study will enroll four groups: individuals with low genetic risk for psychosis and low environmental risk, individuals with low genetic risk for psychosis and high environmental risk, individuals with high genetic risk for psychosis and low environmental risk, and individuals with high genetic risk for psychosis risk and high environmental risk. The research study includes a clinical assessment, neurocognitive assessment, questionnaires about moods and feelings, a blood draw, and an MRI scan.

The results of this study will help us learn more about how environmental adversity and genetic vulnerability affects psychosis risk. Dr. Raquel Gur and Dr. Ruben Gur are the Principal Investigators for this study.


Risk and Resilience to Developmental Stress

Dr. Barzilay’s research study Mechanisms of Resilience to Developmental Stress in Children and Adolescents aims to understand why some people are resilient when experiencing stressful life events as they grow up, while others are susceptible and develop distressing thoughts or emotions.

His research study is open to adolescents and young adults ages 16-30, and includes puzzle-like games on a computer, a 1-hour interview answering questions about your thoughts and feelings, and questionnaires about life history and personality traits. Additionally, participants are asked to provide a blood sample, saliva Sample and a small hair sample- these will be studied to learn about the biological differences between resilience and susceptibility.

The research study lasts approximately 4 hours and study participants will be compensated for their time and travel.


A Translational and Neurocomputational Evaluation of a D1R Partial Agonist for Schizophrenia

This research study is studying PF-0641252 as a possible treatment for early-course schizophrenia, schizoaffective disorder or related psychotic disorder. The National Institute of Mental Health (NIMH) is funding this research study.

The purpose of this research is to test whether an experimental drug can help thinking and memory in people with schizophrenia. If you decide to take part in this research study, the general procedures include some clinical assessments and interviews, some computer tests, bloodwork, and a physical exam. Upon successfully completing the screening process, you would complete 7 total study visits (the first being spread across a few days), 5 of which would be test days involving study treatment with the pill named PF-06412562 in which you will receive a randomized dose.

Study participants will be compensated for their time and travel.

The purpose of this study is to examine the effects of genes and the environment on brain development and behavior in men and women, ages 15 – 30 years old.