Frederick Christian Bennett, M.D. Assistant Professor of Psychiatry
Dr. Bennett's laboratory studies microglia, the brain’s resident immune cells. These mysterious cells play important roles in brain health and disease, but are poorly understood. His lab focuses primarily on two related questions: 1) What are the environmental signals and intrinsic properties that govern microglial function? 2) How do these signals and properties contribute to brain health and disease? To answer these questions, they have developed tools to transplant microglia and other macrophages (including from humans) into the rodent brain, allowing dissection of environmental versus cell intrinsic factors controlling microglial function in health and disease. In parallel, they are adopting brain macrophage transplantation for therapeutic use.
Bennett FC, Bennett ML, Yaqoob F, Mulinyawe SB, Grant GA, Hayden Gephart M, Plowey ED, Barres BA: A Combination of Ontogeny and CNS Environment Establishes Microglial Identity. Neuron 98(6): 1170-1183.e8, June 27, 2018 Notes: doi: 10.1016/j.neuron.2018.05.014. Epub 2018 May 31.
Bohlen CJ, Bennett FC, Tucker AF, Collins HY, Mulinyawe SB, Barres BA: Diverse requirements for microglial survival, specification, and function revealed by defined-medium cultures. Keystone Symposium: Neuroinflammation. Keystone, CO June 2017 Notes: Abstract and Poster.
Bohlen CJ, Bennett FC, Tucker AF, Collins HY, Mulinyawe SB, Barres BA.: Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures. Neuron. 94(4): 759-773.e8, May 17, 2017.
Bohlen CJ, Bennett FC, Tucker AF, Collins HY, Mulinyawe SB, Barres BA. : Diverse requirements for microglial survival, specification, and function revealed by defined-medium cultures. Gordon Research Conference: Glial Biology. Ventura, CA March 2017 Notes: Abstract and Poster.
Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Munch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch DH, Dawson VL, Dawson TM, Stevens B, Barres BA: Neurotoxic reactive astrocytes are induced by activated microglia. Nature 541(7638): 481-487, Jan 26, 2017 Notes: doi: 10.1038/nature21029.
Bennett ML, Bennett FC, Barres B: New tools for studying microglia in the mouse and human CNS. Cold Spring Harbor Glia Meeting, Cold Spring Harbor, NY July 2016 Notes: Abstract and Poster.
Bennett ML, Bennett FC, Liddelow S, Ajami B, Zamanian JL, Fernhoff NB, Mulinyawe SB, Bohlen CJ, Adil A, Tucker A, Weissman IL, Chang EF, Grant GA, Hayden-Gephart M, Barres B.: New tools for studying microglia in the mouse and human CNS. Proceedings of the National Academy of Sciences of the United States of America 113(12): E1738-46, March 22, 2016.
Bennett ML, Bennett FC, Ajami B, Bohlen CJ, Mulinyawe SB, Zamanian JL, Barres BA: What do microglia do? Cold Spring Harbor Glia Meeting, Cold Spring Harbor NY July 2014 Notes: Abstract and Talk.
Kesler SR, Bennett FC, Mahaffey ML, Spiegel D: Regional brain activation during verbal declarative memory in metastatic brain cancer. Clin Cancer Res 15(21): 6665-73, Nov 1 2009.
Constantinescu M, Bennett FC, Jayasekera C, Vidal G, Rogers W, Braddock CH: Acute Q fever with multi-organ involvement. California ACP Meeting, Sacramento, CA Sept 2009 Notes: Abstract and Poster.