Ran Barzilay, M.D., Ph.D. Child and Adolescent Psychiatrist

Ran Barzilay, MD PhD, is a Research Associate at the Lifespan Brain Institute at Children’s Hospital of Philadelphia & UPenn Medicine. Dr. Barzilay is a child and adolescent psychiatrist with background in translational neuroscience ranging from basic molecular neuroscience to clinical studies. He studies a broad range of brain mechanisms that affect developmental psychopathology.Specifically, his work focuses on the effects of developmental stress on psychopathology, attempting to dissect the interplay of host and environmental factors in underpinning patient’s susceptibility versus resilience. Dr. Barzilay is also interested in studying developmental trajectories of brain disorders that involve social cognition deficits like Autism and Schizophrenia.

Contact

BARZILAYR@EMAIL.CHOP.EDU

Titles

Other Titles: 
Research Associate – Children’s Hospital of Philadelphia and University of Pennsylvania, Perelman School of Medicine

Education

Education: 
B.S. - Sackler Faculty of Medicine, Tel Aviv University – 2004 – Preclinical MD Studies
Ph.D. - Sackler Faculty of Medicine, Tel-Aviv University – 2008
M.D. - Sackler Faculty of Medicine, Tel-Aviv University – 2011 – Clinical Studies

Selected Publications

Publications: 
  • Peer Reviewed Manuscripts
    1. Segal-Gavish H., Barzilay R., Rimoni O., Offen D. Voluntary exercise improves cognitive deficits in female dominant-negative DISC1 transgenic mouse model of neuropsychiatric disorders. World Journal Biological Psychiatry. 2017; In press.

    2. Segal-Gavish H, Gazit N, Barhum Y, Ben-Zur T, Taler M, Henry Hornfeld S, Gil-Ad I, Weizman A, Slutsky I, Niwa M, Kamiya A, Sawa A, Offen D, Barzilay R. BDNF Overexpression Prevents Cognitive Deficit Elicited by Adolescent Cannabis Exposure and Host Susceptibility Interaction. Human Molecular Genetics. 2017; 26: 2462-2471.

    3. Perets N., Segal-Gavish H., Gothelf Y., Barzilay R., Barhum Y., Abramov N., Hertz S., Morozov D., London M., Offen D. Long Term Beneficial Effect of Neurotrophic Factors-Secreting Mesenchymal Stem Cells Transplantation in the BTBR Mouse Model of Autism. Behavior Brain Research. 2017; 331:254-260.

    4. Avrahami M., Barzilay R., HarGil M., Weizman A., Watemberg N. Serum Ferritin Levels Are Lower in Children With Tic Disorders Compared with Children Without Tics: A Cross-Sectional Study. J Child Adolescent Psychopharmacology. 2017; 27:192-195.

    5. Barzilay R., Ventorp F.,  Segal H., Aharoni I., Bieber A., Dar S., Vescan M., Globus R., Weizman A., Naor D., Lipton J., Janelidze S., Brundin L., Offen D. CD44 deficiency is associated with increased susceptibility to stress-induced anxiety-like behavior in mice. Journal of Molecular Neuroscience. 2016; 60:548-558.

    6. Zalsman G., Weller A., Shbiro L., Barzilay R., Gutman A., Weizman A., Mann J.J., Wasserman J., Wasserman D.Brain Fiber Tract Analysis Using Diffusion Tensor Imaging Reveals Aberrant Connectivity in a Rat Model of Depression. World Journal Biological Psychiatry. 2016. In press.

    7. Zalsman G., Hawton K., Wasserman D., Van Heeringen K., Arensman E., Sarchiapone M., Carli V., Hoschl C., Barzilay R., Balzas J., Purebl G., Kahn J.P., Saiz P.A., Lipsicas C.B., Bobes J., Cozman D., Hegerl U., Zohar J. Suicide prevention strategies revisited: 10-year systematic review. Lancet Psychiatry. 2016; 3: 646-659.

    8. Barzilay R., Shalit N., Shoval G., Shlosberg D., Mor N., Zweigenhaft N., Weizman A., Krivoy R. Characteristics of Synthetic Cannabinoid and Natural Cannabis Users Admitted to a Psychiatric Hospital: A Comparative study. Journal of Clinical Psychiatry. 2016; 77:e989-e995.

    9. Zalsman G., Siman Tov Y., Tzuriel D., Shoval G., Barzilay R., Tiech Fire N., Sherf M., Mann J.J. Psychological Autopsy of Seventy High School Suicides: Combined Qualitative/Quantitative Approach. European Psychiatry. 2016; 6: 8-14.

    10. Barzilay R., Ventorp F, Erhardt S, Samuelsson M, Träskman-Bendz L, Janelidze S, Weizman A, Offen D, Brundin L. The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability. Journal of Affective Disorders. 2016; 193:349-54.

    11. Barzilay R., Lobel T., Krivoy R., Shlosberg D., Weizman A., Katz N. Elevated C-reactive Protein Levels in Schizophrenia Inpatients is Associated with Aggressive Behavior. European Psychiatry. 2016; 31:8-12

    12. Segal-Gavish H., Karvat G., Barak N., Barzilay R., Ganz J., Edry L., Aharony I., Offen D., Kimchi T. Mesenchymal Stem Cell Transplantation Promotes Neurogenesis and Ameliorates Autism Related Behaviors in BTBR Mice. Journal of Autism Research. 2016; 9: 17-32.

    13. Barzilay R., Kaminitz A., Segal H., Taler M., Offen D., Gil-Ad I., Mechoulam R., Weizman A. Dominant negative DISC1 mutant mice display specific social behavior deficits and aberration in BDNF and cannabinoid receptor expression. World Journal Biological Psychiatry 2014; 15:76-82.

    14. Barzilay R., Ganz J., Sadan O., Ben-Zur T., Bren Z., Hinden N., Taler M. Lev N., Gil-Ad I., Weizman A., Offen D. Mesenchymal stem cells protect against phencyclidine induced insult in vivo and counter-act changes in astrocyte gene expression in vitro. European Neuropsychopharmacology. 2013; 23:1115-1123.

    15. Sadan O, Shemesh N, Barzilay R, Dadon-Nahum M, Blumenfeld-Katzir T, Assaf Y, Yeshurun M, Djaldetti R, Cohen Y, Melamed E, Offen D. Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: A potential therapy for Huntington's disease. Experimental Neurology. 2012; 234:417-427.

    16. Yust-Katz S., Fisher-Shoval Y., Barhum Y., Ben-Zur T., Barzilay R., Lev N., Hod M., Melamed E., Offen D. Placental mesenchymal stromal cells induced into neurotrophic factor-producing cells protect neuronal cells from hypoxia and oxidative stress. Cytotherapy. 2012;14:45-55.

    17. Barzilay R., Ben-Zur T., Sadan O., Bren Z., Tarasenko I., Taler M., Lev N., Uzan R., Gil-Ad I., Melamed E., Weizman A., Offen D. Intra-cerebral human adult stem cells transplantation increases BDNF levels and protects against phencyclidine-induced social deficit in mice. Translational Psychiatry 2011; 1: e61.

    18. Barhum Y., Gai Castro S., Bahat-Stromza M., Barzilay R., Melamed E., Offen D. Intracerebroventricular transplantation of human mesenchymal stem cells induced to secrete neurotrophic factors attenuates clinical symptoms in a mouse model of Multiple Sclerosis. Journal of Molecular Neuroscience. 2010; 41:129-137.

    19. Barzilay R., Sadan O., Melamed E., Offen D. Comparative characterization of bone marrow derived mesenchymal stem cells from four different rat strains. Cytotherapy.2009;11:435-442.

    20. Barzilay R., Ben Zur T., Bulvik S., Melamed E., Offen D. Lentiviral delivery of LMX1a into enhances dopaminergic phenotype in differentiated human bone marrow  mesenchymal stem cells. Stem Cells and Development. 2009; 18: 591-601.

    21. Sadan O., Shemesh N., Barzilay R., Bahat-Stromza M., Melamed E., Cohen Y., Offen D. Migration of neurotrophic factors-secreting mesenchymal stem cells towards a quinolinic acid lesion as viewed by MRI. Stem Cells. 2008; 26: 2542-2551.

    22. Barzilay R., Kan I, Ben Zur T., Bulvik S.,  Melamed E., Offen D. Induction of Human Mesenchymal Stem Cells into Dopamine-Producing Cells with Different Differentiation Protocols. Stem Cells and Development. 2008;17: 547-554.

    23. Levy Y.S., Bahat Stromza M., Barzilay R., Burshtein A., Bulvik S., Barhum Y., Panet H., Melamed E., Offen D. Regenerative effect of neural induced mesenchymal stem cells in rat models of Parkinson’s disease. Cytotherapy. 2008; 10: 340-352.

    24. Blondheim NR, Levy YS, Ben-Zur T, Burshtein A, Cherlow T, Kan I, Barzilai R, Bahat-Stromza M, Barhum Y, Bulvik S, Melamed E, Offen D. Human mesenchymal stem cells express neural genes, suggesting a neural predisposition. Stem Cells and Development. 2006;15: 141-164.

  • Review Articles Published in Scientific Journals

  1. Barzilay R., Melamed E., Offen D.: Introducing Transcription Factors to Multipotent Mesenchymal Stem Cells- Making Transdifferentiation Possible. Stem Cells.  2009; 27: 2509-2515.
  2. Barzilay R., Levy Y.S., Melamed E., Offen D.; Adult stem cells for neuronal repair. Isr Med Assoc J. 2006. 8: 61-66.
  • Book Chapters
  1. Laor N., Nagel-Edelstein T., Barzilay R., Golan O. Israel and Autism. Book Chapter in “Encyclopedia of Autism Spectrum Disorders” Volkmar F.R. (Eds.), Springer. In Press.
  2. Barzilay R.; Bone Marrow Stem Cells for Neural Rescue: Prospects of Cellular Therapy. Book Chapter in "The Molecular Basis of Neurodegenerative Diseases" Offen D. and Lev N. (Eds.), Research Signpost. 2008.